Although the neurotoxic effects of homocysteine have been well elucidated, the effects of
homocysteine in astrocytes have received little attention until recently. Previously we have
demonstrated that elevated levels of homocysteine caused significant metabolic changes
and altered mitochondrial function in primary cultures of astrocytes. However, the
mechanisms behind such alterations remain unclear. As homocysteine is a key metabolite in
one-carbon metabolism the present study examined if the effects of homocysteine on …