How does osteocalcin lacking γ-glutamic groups affect biomimetic apatite formation and what can we say about its structure in mineral-bound form?
T Iline-Vul, A Kulpanovich, M Nadav-Tsubery… - Journal of Structural …, 2019 - Elsevier
Non-collagenous proteins such as osteocalcin function as regulators of the mineralization
process in bone. Osteocalcin undergoes post-translational modification adding an extra
carboxylate group on three of its glutamate residues to enhance interaction with bone
mineral. In this work, we examine regulation of biomimetic apatite formation by osteocalcin
that was not modified after translation. We analyze the structural features in the protein and
mineral-protein interfaces to elicit the unmodified protein's fold inside the mineral and to …
process in bone. Osteocalcin undergoes post-translational modification adding an extra
carboxylate group on three of its glutamate residues to enhance interaction with bone
mineral. In this work, we examine regulation of biomimetic apatite formation by osteocalcin
that was not modified after translation. We analyze the structural features in the protein and
mineral-protein interfaces to elicit the unmodified protein's fold inside the mineral and to …
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