How to use and interpret the results of a platform trial: users' guide to the medical literature

JJH Park, MA Detry, S Murthy, G Guyatt, EJ Mills - Jama, 2022 - jamanetwork.com
Platform trials are a type of randomized clinical trial that allow simultaneous comparison of
multiple intervention groups against a single control group that serves as a common control
based on a prespecified interim analysis plan. The platform trial design enables introduction
of new interventions after the trial is initiated to evaluate multiple interventions in an ongoing
manner using a single overarching protocol called a master (or core) protocol. When
multiple treatment candidates are available, rapid scientific therapeutic discoveries may be …
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