Human D-amino acid oxidase: structure, function, and regulation

L Pollegioni, S Sacchi, G Murtas - Frontiers in Molecular Biosciences, 2018 - frontiersin.org
D-Amino acid oxidase (DAAO) is an … D-amino acids, the only exception being the acidic
ones. This flavoenzyme plays different roles during evolution and in different tissues in humans. …

D-amino acid oxidase: physiological role and applications

SV Khoronenkova, VI Tishkov - Biochemistry (Moscow), 2008 - Springer
… Abstract—D Amino acids play a key role in regulation of … of D amino acids that play an
important role in the regulation of … Changes in the levels of D amino acids have a major impact on …

Physiological functions of D-amino acid oxidases: from yeast to humans

L Pollegioni, L Piubelli, S Sacchi, MS Pilone… - Cellular and molecular …, 2007 - Springer
… distinct physiological functions: from a catabolic role in yeast cells, which allows them to
grow on D-amino acids as carbon and energy sources, to a regulatory role in the human brain, …

Biochemical properties of human D-amino acid oxidase

G Murtas, S Sacchi, M Valentino… - Frontiers in Molecular …, 2017 - frontiersin.org
regulating D-serine … function in catabolizing exogenous D-amino acids. In the last few years,
however, a key role in the metabolism of D-amino acids with specific physiological function

Competitive inhibitors unveil structure/function relationships in human D-amino acid oxidase

G Molla - Frontiers in Molecular Biosciences, 2017 - frontiersin.org
D-amino acid oxidase (DAAO) catalyzes the oxidative deamination of several neutral D-amino
acids and … This D-amino acid, which binds the coagonist site of the N-methyl-D-aspartate …

Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies

S Sacchi, P Cappelletti, G Murtas - Frontiers in molecular biosciences, 2018 - frontiersin.org
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids, …

D-Amino-acid oxidase and its physiological function

K Ryuichi, Y Yosihiro - International journal of biochemistry, 1992 - Elsevier
function is not known since its substrates, D-amino acids, are rare in higher animals. D-Amino-acid
oxidase … Antibodies raised against pig kidney D-amino-acid oxidase reacted with a …

Structurefunction relationships in human d-amino acid oxidase variants corresponding to known SNPs

P Cappelletti, L Piubelli, G Murtas, L Caldinelli… - … et Biophysica Acta (BBA …, 2015 - Elsevier
… In the brain, d-amino acid oxidase plays a key role in modulating the N-methyl-d-aspartate …
the regulation of d-serine levels, may affect the NMDAR-dependent physiological functions (…

Human D-aspartate oxidase: a key player in D-aspartate metabolism

L Pollegioni, G Molla, S Sacchi… - Frontiers in Molecular …, 2021 - frontiersin.org
human d-amino acid oxidase (hDAAO), the enzyme that degrades neutral and basic d-amino
acids… and current knowledge regarding the regulation of enzyme activity and expression, …

An overview on d-amino acids

G Genchi - Amino acids, 2017 - Springer
… by activating the expression of Steroidogenic Acute Regulatory (StAR) protein. … to regulate
d-Asp homeostasis, as they can synthesize, release, take up, and degrade the amino acid. …