Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor α (PPARα)
A Fernández-Alvarez, MS Alvarez, R Gonzalez… - Journal of Biological …, 2011 - ASBMB
Sterol regulatory element binding proteins (SREBPs) regulate the expression of a number of
enzymes, which catalyze the synthesis of fatty acids, cholesterol, triglycerides, and
phospholipids. SREBP1c is the most relevant isoform in the adult liver, and its expression is
controlled by the nutritional state. Transcriptional regulation studies into the SREBP1c gene,
performed in the last few years, have improved our knowledge of the variability of signals
that converge on its promoter region. Insulin, cholesterol derivatives, T3 and other …
enzymes, which catalyze the synthesis of fatty acids, cholesterol, triglycerides, and
phospholipids. SREBP1c is the most relevant isoform in the adult liver, and its expression is
controlled by the nutritional state. Transcriptional regulation studies into the SREBP1c gene,
performed in the last few years, have improved our knowledge of the variability of signals
that converge on its promoter region. Insulin, cholesterol derivatives, T3 and other …
[PDF][PDF] Human SREBP1c Expression in Liver Is Directly Regulated by Peroxisome Proliferator-activated Receptor (PPAR)
M Casado - THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2011 - academia.edu
Sterol regulatory element binding proteins (SREBPs) regulate the expression of a number of
enzymes, which catalyze the synthesis of fatty acids, cholesterol, triglycerides, and
phospholipids. SREBP1c is the most relevant isoform in the adult liver, and its expression is
controlled by the nutritional state. Transcriptional regulation studies into the SREBP1c gene,
performed in the last few years, have improved our knowledge of the variability of signals
that converge on its promoter region. Insulin, cholesterol derivatives, T3 and other …
enzymes, which catalyze the synthesis of fatty acids, cholesterol, triglycerides, and
phospholipids. SREBP1c is the most relevant isoform in the adult liver, and its expression is
controlled by the nutritional state. Transcriptional regulation studies into the SREBP1c gene,
performed in the last few years, have improved our knowledge of the variability of signals
that converge on its promoter region. Insulin, cholesterol derivatives, T3 and other …
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