Liver transplantation is the only choice for patients with end-stage liver diseases. Hepatocyte transplantation is a promising alternative for treatment of these groups. However, the major challenge is insufficiency of donor organs that can provide good-quality cells. Therefore, numerous experimental and clinical studies have evaluated the potential of different sources of adult stem cells, which differentiate into hepatocytes, for cell therapy. Endometrial (stem) stromal cells are readily isolated and expandable; moreover, these cells have more clonogenicity and pose less technical problems, so they are considered to possess great autologous therapeutic potential.

We propose that endometrial stem (stromal) cells could be an invaluable and realistic source in this regard.