Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and …
L Wu, W Zhong, J Liu, W Han, S Zhong, Q Wei, S Liu… - Fitoterapia, 2015 - Elsevier
Oxysophocarpine (OSC), an active and toxic quinolizidine alkaloid, is highly valued in
Sophora flavescens Ait. and Subprostrate sophora Root. OSC is used to treat inflammation
and hepatitis for thousands of years in China. This study aims to investigate the CYP450-
mediated reduction responsible for metabolizing OSC and to evaluate the absorption and
metabolism of OSC in rat in situ. Four metabolites were identified, with sophocarpine (SC) as
the major metabolite. SC formation was rapid in human and rat liver microsomes (HLMs and …
Sophora flavescens Ait. and Subprostrate sophora Root. OSC is used to treat inflammation
and hepatitis for thousands of years in China. This study aims to investigate the CYP450-
mediated reduction responsible for metabolizing OSC and to evaluate the absorption and
metabolism of OSC in rat in situ. Four metabolites were identified, with sophocarpine (SC) as
the major metabolite. SC formation was rapid in human and rat liver microsomes (HLMs and …
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