… metastatic tumor cells… tumors (5) suggests that the antimetastatic factor is an angiogenesis
inhibitor. We now report that PC-3 cells secrete enzymatic activity able to cleave plasminogen …

… and convert the inactive zymogen plasminogen to plasmin. Plasmin is a proteolytic enzyme
… • 18 in addition to its well characterized fibrinolytic action. Degradation of these extracellular …

… ability of human PRCA cell lines to produce plasmin on their surface and the possible
involvement of plasmin itself in the proliferative response of these cells. … Enzymatic activities were …

… plasminogen activation primarily by uPA, as shown by two different colorimetric enzyme
activity … 2,B, the SF-CM of DU145 cells was active in converting Glu-plasminogen to plasmin,…

… pericellular proteolysis via their activity in converting plasminogen to plasmin in the fibrinolytic
… cDNA probes for uPA, tPA, PAI1, and PA12 transcripts, and the cellular enzyme GAPDH …

… produce identical or similar enzymes which are capable of activating the fibrinolytic system
by converting plasminogen to the active protease plasmin. It could be shown that almost all of …

… lines originating from the rat Dunning R-3327 prostate tumor … degradation, enzyme activity,
and mRNA levels of enzymes, … conversion of plasminogen to the active protease plasmin …

… of an enzymatic complex with factor VII/… cell surface–bound TF on 1-LN human prostate
tumor cells with high affinity, and binding is not inhibited by Pg 2. Bound Pg 1 is rapidly converted …

… of plasmin involves the pro-enzyme plasminogen, the … It is converted locally to the active
serine protease plasmin by … (42), and by macrophages and neutrophils in prostate cancer (39). …

… Enzymatic activity was determined following subtraction of … media or cell extracts incubated
without plasminogen from … experiments on plasmin binding to cells we used human plasmin (…