Hyaluronan content governs tissue stiffness in pancreatic islet inflammation
N Nagy, A De La Zerda, G Kaber, PY Johnson… - Journal of Biological …, 2018 - ASBMB
We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in
governing the mechanical properties of inflamed tissues. We recently reported that insulitis
in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly
hygroscopic polymer. Using the double transgenic DO11. 10× RIPmOVA (DORmO) mouse
model of type 1 diabetes, we asked whether autoimmune insulitis was associated with
changes in the stiffness of islets. To measure islet stiffness, we used atomic force microscopy …
governing the mechanical properties of inflamed tissues. We recently reported that insulitis
in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly
hygroscopic polymer. Using the double transgenic DO11. 10× RIPmOVA (DORmO) mouse
model of type 1 diabetes, we asked whether autoimmune insulitis was associated with
changes in the stiffness of islets. To measure islet stiffness, we used atomic force microscopy …
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