Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells
MML Dingemans, A De Groot… - Environmental …, 2008 - ehp.niehs.nih.gov
Background Oxidative metabolism, resulting in the formation of hydroxylated polybrominated
diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated
flame retardants. Objective Our objective was to investigate the effects of a hydroxylated
metabolite of 2, 2′, 4, 4′-tetra-bromodiphenyl ether (BDE-47; 6-OH-BDE-47) on changes
in the intracellular Ca2+ concentration ([Ca2+] i) and vesicular catecholamine release in
PC12 cells. Methods We measured vesicular catecholamine release and [Ca2+] i using …
diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated
flame retardants. Objective Our objective was to investigate the effects of a hydroxylated
metabolite of 2, 2′, 4, 4′-tetra-bromodiphenyl ether (BDE-47; 6-OH-BDE-47) on changes
in the intracellular Ca2+ concentration ([Ca2+] i) and vesicular catecholamine release in
PC12 cells. Methods We measured vesicular catecholamine release and [Ca2+] i using …
以上显示的是最相近的搜索结果。 查看全部搜索结果