Background Emerging evidence indicates that the cyclic GMP-AMP synthase-stimulator of
interferon genes (cGAS-STING) axis plays a pivotal role in intrinsic antitumor immunity.
Previous studies demonstrate that the conventional chemotherapy agent, teniposide,
effectively promotes the therapeutic efficacy of programmed cell death protein-1 antibody
(PD-1 Ab) through robust cGAS-STING activation. Unfortunately, the cGAS expression of
tumor cells is reported to be severely suppressed by the hypoxic status in solid tumor …

Recently, we followed the report by Yang et al that hyperbaric oxygen facilitates
teniposideinduced The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes
(STING) pathway (cGAS-STING) activation to enhance the antitumor efficacy of an anti-PD-1
antibody in Hepatocellular carcinoma (HCC) with interest. 1 The authors provided new
insight into hyperbaric oxygen and teniposide chemotherapy, showing that this combination
could synergistically trigger efficient tumor STING activation and eventually stimulate a …