Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats
BM McGowan, SA Stanley, NE White… - American Journal …, 2007 - journals.physiology.org
The insulin superfamily, characterized by common disulphide bonds, includes not only
insulin but also insulin-like peptides such as relaxin-1 and relaxin-3. The actions of relaxin-3
are largely unknown, but recent work suggests a role in regulation of food intake. Relaxin-3
mRNA is highly expressed in the nucleus incertus, which has extensive projections to the
hypothalamus, and relaxin immunoreactivity is present in several hypothalamic nuclei. In the
rat, relaxin-3 binds and activates both relaxin family peptide receptor 1, which also binds …
insulin but also insulin-like peptides such as relaxin-1 and relaxin-3. The actions of relaxin-3
are largely unknown, but recent work suggests a role in regulation of food intake. Relaxin-3
mRNA is highly expressed in the nucleus incertus, which has extensive projections to the
hypothalamus, and relaxin immunoreactivity is present in several hypothalamic nuclei. In the
rat, relaxin-3 binds and activates both relaxin family peptide receptor 1, which also binds …
Hypothalamic mapping of orexigenic action and fos-like immunoreactivity following relaxin-3 administration in male Wistar rats
ELT PATTERSON, KL SMITH, J DONOVAN… - 2006 - journals.physiology.org
The insulin superfamily, characterized by common disulphide bonds, includes not only
insulin but also insulin-like peptides such as relaxin-1 and relaxin-3. The actions of relaxin-3
are largely unknown but recent work suggests a role in regulation of food intake. Relaxin-3
mRNA is highly expressed in the nucleus incertus which has extensive projections to the
hypothalamus and relaxin immunoreactivity is present in several hypothalamic nuclei. In the
rat, relaxin-3 binds and activates both RXFP1, which also binds relaxin-1, and a previously …
insulin but also insulin-like peptides such as relaxin-1 and relaxin-3. The actions of relaxin-3
are largely unknown but recent work suggests a role in regulation of food intake. Relaxin-3
mRNA is highly expressed in the nucleus incertus which has extensive projections to the
hypothalamus and relaxin immunoreactivity is present in several hypothalamic nuclei. In the
rat, relaxin-3 binds and activates both RXFP1, which also binds relaxin-1, and a previously …
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