… multiple sclerosis lesions, hypoxia and inflammation have an intertwined relationship whereby
transient hypoxic … system could augment tissue hypoxia. These events would establish a ‘…

… multiple sclerosis (MS) are heterogenous. In this review, evidence is discussed, which show
that in a subset of multiple sclerosis … , thus suggesting that a hypoxia-like metabolic injury is …

Multiple sclerosis (MS), an inflammatory demyelinating disease, is a major cause of
neurological disability in young adults in the developed world. Although the progressive …

… Here, we review the evidence suggesting that diffuse hypoxia is present in MS and propose
that there is an “hypoxia–inflammation cycle” (Figure 1) that contributes to MS disease …

… Progressive multiple sclerosis (MS) is a severely disabling … caused by a state of virtual
hypoxia within the neuron. Accordingly, … axonal hypoxia through enhanced energy production. …

… multiple sclerosis (MS), suggesting that common pathogenic mechanisms may be involved
in this injury. Here we consider the potential pathogenic role of tissue hypoxia … is hypoxic (as …

… , 16 and our group has reported evidence of hypoxic-like damage in a subset of WM lesions,
11 we have also looked at the hypoxia-associated D110 molecule. This data was correlated …

… In the course of a systematic screening for virus antigen expression in multiple sclerosis …
multiple sclerosis lesions with little or no immunoreactivity in other active multiple sclerosis cases…

… Multiple sclerosis (MS) has a significant inflammatory component and may … and hypoxia are
interdependent. In this paper, we applied novel, implanted PO 2 sensors to measure hypoxia …

… The evidence that hypoxia is a precipitating factor in causing early MS … of hypoxia-inducible
factor-1α; presence of the D-110 hypoxia-inducible protein; increased expression of hypoxia-…