IFN-γ signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS
H Lin, BP Scull, BR Goldberg, HA Abhyankar… - Blood …, 2021 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by pathologic
immune activation in which prompt recognition and initiation of immune suppression is
essential for survival. Children with HLH have many overlapping clinical features with
critically ill children with sepsis and systemic inflammatory response syndrome (SIRS) in
whom alternative therapies are indicated. To determine whether plasma biomarkers could
differentiate HLH from other inflammatory conditions and to better define a core inflammatory …
immune activation in which prompt recognition and initiation of immune suppression is
essential for survival. Children with HLH have many overlapping clinical features with
critically ill children with sepsis and systemic inflammatory response syndrome (SIRS) in
whom alternative therapies are indicated. To determine whether plasma biomarkers could
differentiate HLH from other inflammatory conditions and to better define a core inflammatory …
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