Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair
J Godau, LP Ferretti, A Trenner, E Dubois… - DNA repair, 2019 - Elsevier
DNA double-strand breaks (DSBs) induced by genotoxic agents can cause cell death or
contribute to chromosomal instability, a major driving force of cancer. By contrast, Spo11-
dependent DSBs formed during meiosis are aimed at generating genetic diversity. In
eukaryotes, CtIP and the Mre11 nuclease complex are essential for accurate processing and
repair of both unscheduled and programmed DSBs by homologous recombination (HR).
Here, we applied bioinformatics and genetic analysis to identify Paramecium tetraurelia CtIP …
contribute to chromosomal instability, a major driving force of cancer. By contrast, Spo11-
dependent DSBs formed during meiosis are aimed at generating genetic diversity. In
eukaryotes, CtIP and the Mre11 nuclease complex are essential for accurate processing and
repair of both unscheduled and programmed DSBs by homologous recombination (HR).
Here, we applied bioinformatics and genetic analysis to identify Paramecium tetraurelia CtIP …
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