Identification of Components of the Hippo Pathway in Hydra and Potential Role of YAP in Cell Division and Differentiation
The Hippo signaling pathway has been shown to be involved in regulating cellular identity,
cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a
kinase cascade which determines the nucleo-cytoplasmic localization of YAP in the cell.
YAP is the effector protein in the Hippo pathway, which acts as a transcriptional cofactor for
TEAD. Phosphorylation of YAP upon activation of the Hippo pathway prevents it from
entering the nucleus and abrogates its function in the transcription of the target genes. In …
cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a
kinase cascade which determines the nucleo-cytoplasmic localization of YAP in the cell.
YAP is the effector protein in the Hippo pathway, which acts as a transcriptional cofactor for
TEAD. Phosphorylation of YAP upon activation of the Hippo pathway prevents it from
entering the nucleus and abrogates its function in the transcription of the target genes. In …
Identification of Components of the Hippo Pathway in Hydra and Potential Role of YAP in Cell Division and Differentiation
The Hippo signaling pathway has been shown to be involved in regulating cellular identity,
cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a
kinase cascade which determines the nucleo-cytoplasmic localization of YAP in the cell.
YAP is the effector protein in the Hippo pathway, which acts as a transcriptional cofactor for
TEAD. Phosphorylation of YAP upon activation of the Hippo pathway prevents it from
entering the nucleus and abrogates its function in the transcription of the target genes. In …
cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a
kinase cascade which determines the nucleo-cytoplasmic localization of YAP in the cell.
YAP is the effector protein in the Hippo pathway, which acts as a transcriptional cofactor for
TEAD. Phosphorylation of YAP upon activation of the Hippo pathway prevents it from
entering the nucleus and abrogates its function in the transcription of the target genes. In …
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