The function of dopamine D 3 receptors present in the striatum has remained elusive. In the
present study evidence is provided for the existence of dopamine D 1–D 3 receptor
heteromers and for an intramembrane D 1–D 3 receptor cross-talk in living cells and in the
striatum. The formation of D 1–D 3 receptor heteromers was demonstrated by fluorescence
resonance energy transfer and bioluminescence resonance energy transfer techniques in
transfected mammalian cells. In membrane preparations from these cells, a synergistic D 1 …

The function of dopamine D3 receptors present in the striatum has remained elusive. In the
present study evidence is provided for the existence of dopamine D1–D3 receptor
heteromers and for an intramembrane D1–D3 receptor cross-talk in living cells and in the
striatum. The formation of D1–D3 receptor heteromers was demonstrated by fluorescence
resonance energy transfer and bioluminescence resonance energy transfer techniques in
transfected mammalian cells. In membrane preparations from these cells, a synergistic D1 …