Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae
HT Sojar, RJ Genco - FEMS Immunology & Medical …, 2005 - academic.oup.com
Binding of Porphyromonas gingivalis to the host cells is an essential step in the
pathogenesis of periodontal disease. P. gingivalis binds to and invades epithelial cells, and
fimbriae are thought to be involved in this process. In our earlier studies, two major epithelial
cell components of 40 and 50 kDa were identified as potential fimbrial receptors.
Sequencing of a cyanogen bromide digestion fragment of the 50-kDa component resulted in
an internal sequence identical to keratin I molecules, and hence this cytokeratin represents …
pathogenesis of periodontal disease. P. gingivalis binds to and invades epithelial cells, and
fimbriae are thought to be involved in this process. In our earlier studies, two major epithelial
cell components of 40 and 50 kDa were identified as potential fimbrial receptors.
Sequencing of a cyanogen bromide digestion fragment of the 50-kDa component resulted in
an internal sequence identical to keratin I molecules, and hence this cytokeratin represents …
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