Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This
spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment
of the early stage progression of the disease but combinational therapy is more preferred in
later stages. Research is in progress for the development of drugs against the pathogen, but
till date no vaccines have been developed to effect the late stage infections. There is a rapid
rise in the cases of antibiotic-resistant population which is more than 10% of the total …

… Thus, a comprehensive list of drug targets unique to the microorganisms is often necessary.
Availability of Borrelia burgdorferi ZS7 proteome has enabled insilico analysis of protein
sequences for the identification of drug targets and vaccine targets. In this study, 272 essential
proteins were identified out of which 42 proteins were unique to the microorganism. The study …