Identification of the Axin and Frat binding region of glycogen synthase kinase-3
E Fraser, N Young, R Dajani, J Franca-Koh… - Journal of Biological …, 2002 - ASBMB
Glycogen synthase kinase-3 (GSK-3) is a key component of several signaling pathways
including those regulated by Wnt and insulin ligands. Specificity in GSK-3 signaling is
thought to involve interactions with scaffold proteins that localize GSK-3 regulators and
substrates. This report shows that GSK-3 forms a low affinity homodimer that is disrupted by
binding to Axin and Frat. Based on the crystal structure of GSK-3, we have used surface-
scanning mutagenesis to identify residues that differentially affect GSK-3 interactions …
including those regulated by Wnt and insulin ligands. Specificity in GSK-3 signaling is
thought to involve interactions with scaffold proteins that localize GSK-3 regulators and
substrates. This report shows that GSK-3 forms a low affinity homodimer that is disrupted by
binding to Axin and Frat. Based on the crystal structure of GSK-3, we have used surface-
scanning mutagenesis to identify residues that differentially affect GSK-3 interactions …
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