[HTML][HTML] Identification of two α-subunit species of GTP-binding proteins, Gα15 and Gαq, expressed in rat taste buds
Y Kusakabe, E Yamaguchi, K Tanemura… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Y Kusakabe, E Yamaguchi, K Tanemura, K Kameyama, N Chiba, S Arai, Y Emori, K Abe
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1998•ElsevierWe cloned cDNAs for two G protein α-subunits belonging to the Gαq family, each capable of
activating PLCβ, from rat tongue. One is a Gαq in the narrow sense, and the other, termed rat
Gα15, is a rat counterpart of mouse Gα15, sharing an amino acid sequence similarity of
94%. RT-PCR and Northern blot analysis demonstrated that rat Gα15 and Gαq were
distinctly expressed in tongue epithelia containing taste buds. Immunostaining also showed
that rat Gα15, together with the Gαq, was localized mainly in taste buds. These studies …
activating PLCβ, from rat tongue. One is a Gαq in the narrow sense, and the other, termed rat
Gα15, is a rat counterpart of mouse Gα15, sharing an amino acid sequence similarity of
94%. RT-PCR and Northern blot analysis demonstrated that rat Gα15 and Gαq were
distinctly expressed in tongue epithelia containing taste buds. Immunostaining also showed
that rat Gα15, together with the Gαq, was localized mainly in taste buds. These studies …
We cloned cDNAs for two G protein α-subunits belonging to the Gαq family, each capable of activating PLCβ, from rat tongue. One is a Gαq in the narrow sense, and the other, termed rat Gα15, is a rat counterpart of mouse Gα15, sharing an amino acid sequence similarity of 94%. RT-PCR and Northern blot analysis demonstrated that rat Gα15 and Gαq were distinctly expressed in tongue epithelia containing taste buds. Immunostaining also showed that rat Gα15, together with the Gαq, was localized mainly in taste buds. These studies suggest the possibility that these two Gα proteins function for taste signal transduction in sensory cells.
Elsevier
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