IgLON5 antibody: neurological accompaniments and outcomes in 20 patients
JA Honorat, L Komorowski, KA Josephs… - Neurology …, 2017 - AAN Enterprises
Objective: To describe the phenotypes, treatment response, and outcome of IgLON5
autoimmunity. Methods: Archived serum and CSF specimens from 367 patients known to
harbor unclassified antibodies which stained neural synapses diffusely (mimicking
amphiphysin-IgG) were reevaluated by indirect immunofluorescence assay (IFA) using a
composite of mouse tissues and recombinant IgLON5-transfected cell-based assay (CBA,
Euroimmun). Results: Available specimens (serum, 25; CSF, 9) from 26/367 patients (7%) …
autoimmunity. Methods: Archived serum and CSF specimens from 367 patients known to
harbor unclassified antibodies which stained neural synapses diffusely (mimicking
amphiphysin-IgG) were reevaluated by indirect immunofluorescence assay (IFA) using a
composite of mouse tissues and recombinant IgLON5-transfected cell-based assay (CBA,
Euroimmun). Results: Available specimens (serum, 25; CSF, 9) from 26/367 patients (7%) …
[引用][C] IgLON5 antibody. Neurological accompaniments and outcomes in 20 patients. Neurol Neuroimmunol Neuroinflamm. 2017; 4 (5): e385
JA Honorat, L Komorowski, KA Josephs, K Fechner… - Description of another series of