Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors

B Jin, N Thakur, AV Wijesekara, MT Eddy - Current Opinion in …, 2023 - Elsevier
G protein-coupled receptors (GPCRs) exhibit remarkable structural plasticity, which
underlies their capacity to recognize a wide range of extracellular molecules and interact
with intracellular partner proteins. Nuclear magnetic resonance (NMR) spectroscopy is
uniquely well-suited to investigate GPCR structural plasticity, enabled by stable-isotope
“probes” incorporated into receptors that inform on structure and dynamics. Progress with
stable-isotope labeling methods in Eukaryotic expression systems has enabled production …
以上显示的是最相近的搜索结果。 查看全部搜索结果