In the last two decades, a variety of techniques for signal‐to‐noise ratio (SNR) estimation in scanning electron microscope (SEM) images have been proposed. However, these techniques can be divided into two groups: first, SNR estimators of good accuracy, but based on impractical assumptions; second, estimators based on realistic assumptions but of poor accuracy. In this paper we propose the implementation of autoregressive (AR)‐model interpolation as a solution to the problem. Unlike others, the proposed technique is based on a single SEM image and offers the required accuracy and robustness in estimating SNR values.