Immune imprinting and protection against repeat reinfection with SARS-CoV-2
New England Journal of Medicine, 2022•Mass Medical Soc
… Evidence at the level of binding and neutralizing antibodies and B-cell and T-cell immunity
suggests that a history of infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can have a negative effect on subsequent protective immunity. In particular, the
… We investigated the epidemiologic evidence for immune imprinting in persons with specific
immune histories related to natural infection. We evaluated the incidence of repeat reinfection
in the national cohort of persons in Qatar who had had a documented omicron BA.1 or BA.2 …
suggests that a history of infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can have a negative effect on subsequent protective immunity. In particular, the
… We investigated the epidemiologic evidence for immune imprinting in persons with specific
immune histories related to natural infection. We evaluated the incidence of repeat reinfection
in the national cohort of persons in Qatar who had had a documented omicron BA.1 or BA.2 …
Immune Responses to SARS-CoV-2 Reinfection
Evidence from this cohort study suggests that an earlier infection with pre-omicron SARS-CoV-2 before a first omicron infection may broaden the immune response against a future reinfection challenge.
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