In clinical practices, the examination of pentamer C-reactive protein (pCRP) is commonly
used as a prognostic indicator of the risk of a patient developing cardiovascular disease
(CVD). Structural modification of pCRP produces a modified CRP (mCRP) which exhibits
different biological activities in the body. In recent years, mCRP has come to be regarded as
a more powerful inducer than pCRP, and hence mCRP measurement has emerged as an
important indicator for assessing the risk of developing CVD. The surface plasmon …

This study performs an immunoassay equipped with surface plasmon resonance (SPR) for
real-time and label-free investigation of C-reactive protein (CRP). CRP has at least two
forms, the larger known as native CRP (nCRP) consisting of five identical polypeptide
subunits linked together by noncovalent bonds, and the smaller named as modified CRP
(mCRP) generated from structural modification of nCRP. Some studies regarded mCRP as a
more powerful inducer than nCRP in predicting cardiovascular and coronary diseases …