Enterobiasis vermicularis (Ev), considered the most common helminthic infection in the world. Approximately 4% to 28% of children infected with Ev. Sidr (Zizyphus Spina-Christi) leaf has many therapeutic effects. The aim of the study promising anti-Ev agents by using Sidr extracts leaves. Choosing the Ev infected from150 male children (7-10 yrs.), 5 children served as the normal control group and 25 children whose stool were infected with Ev. The data indicated the children treated with Sidr extracts at two levels (10 or 20 mg/day) where the (Pus cells & RBC's and Ova counts) in the stool decreased significantly from the first to the second week. After the continuation treat with Sidr, the Ev and Ova completely disappeared in the third week in dose 10 mg and second weeks of the dose 20 mg of Sidr. Furthermore, the children treated having improved significantly (P≤ 0.001) in (HB, RBC's, and WBC's) parameters.