Impact of chronic renal failure and peritoneal dialysis fluids on advanced glycation end product and iNOS levels in penile tissue: an experimental study

MF Usta, M Tuncer, A Baykal, MA Çiftçioğlu, T Erdoğru… - Urology, 2002 - Elsevier
Objectives. To investigate the impact of chronic renal failure (CRF) on advanced glycation
end product and inducible nitric oxide synthase (iNOS) in penile tissue, we examined the
advanced glycation end product 5-hydroxy methyl furfural (5-HMF) content and iNOS
expression in rats in which uremia had been produced by greater than 85% nephrectomy. In
addition, the contribution of peritoneal dialysis (PD) fluids to the elevation of penile tissue 5-
HMF levels and iNOS staining scores has been investigated. Methods. Adult male Wistar …
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