Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development

M Borzio, S Fargion, F Borzio, AL Fracanzani… - Journal of …, 2003 - Elsevier
Background/Aims: The natural outcome of ultrasound-detected macronodules in cirrhosis is
still poorly understood. In this study we assessed the incidence and predictors of malignant
transformation in a prospective study of 90 consecutive ultrasound-detected macronodules
in cirrhosis. Methods: Macronodules classification was based on recently proposed
histological criteria. Extranodular large (LCC) and small cell changes were also evaluated.
The follow-up included ultrasound and serum alfa-fetoprotein determination every 3 months …
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