Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice
Background Growing evidence supports the role of gut microbiota in obesity and its related
disorders including type 2 diabetes. Ob/ob mice, which are hyperphagic due to leptin
deficiency, are commonly used models of obesity and were instrumental in suggesting links
between gut microbiota and obesity. Specific changes in their gut microbiota such as
decreased microbial diversity and increased Firmicutes to Bacteroidetes ratio have been
suggested to contribute to obesity via increased microbiota capacity to harvest energy …
disorders including type 2 diabetes. Ob/ob mice, which are hyperphagic due to leptin
deficiency, are commonly used models of obesity and were instrumental in suggesting links
between gut microbiota and obesity. Specific changes in their gut microbiota such as
decreased microbial diversity and increased Firmicutes to Bacteroidetes ratio have been
suggested to contribute to obesity via increased microbiota capacity to harvest energy …
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