Stem cells are exciting candidates for therapeutic strategies in neurodegenerative diseases,
due to their multipotency and migratory capabilities. We show that stem cell-like embryonic
normal human neural progenitors (HNPs) are capable of proliferating in response to
mitogenic growth factors and differentiate into diverse CNS cell types in vitro. We present
evidence that HNPs differentiate to βIII-tubulin-, glial fibrillary acidic protein-and O4-immuno-
positive cells, in both a fetal bovine serum-containing and a non-supplemented, serum-free …