In vitro interactions of coumarins with iron

P Mladěnka, K Macáková, L Zatloukalová, Z Řeháková… - Biochimie, 2010 - Elsevier
Coumarins are a large group of natural substances with diverse pharmacological properties
that may predetermine some of them for the prevention and/or treatment of cardiovascular
diseases and also other pathologies. Free iron participates in the production of reactive
oxygen species (ROS) and plays an important role in the pathogenesis of cardiovascular
diseases. Therefore, chelation of iron may attenuate some ROS consequences, but on the
other hand, reduction of ferric ions to ferrous ones is unfavourable and leads to …
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