Objective Adiponectin and the signaling induced by its cognate receptors, AdipoR1 and
AdipoR2, have garnered attention for their ability to promote insulin sensitivity and oppose
steatosis. Activation of these receptors promotes the deacylation of ceramide, a lipid
metabolite that appears to play a causal role in impairing insulin signaling. Methods Here,
we have developed transgenic mice that overexpress AdipoR1 or AdipoR2 under the
inducible control of a tetracycline response element. These represent the first inducible …