The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory
receptors on CD4+ T cells promotes autoimmunity, whereas sustained overexpression on
CD8+ T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear
chronic viral infections and diseases such as cancer,. Here, using RNA and protein
expression profiling at single-cell resolution in mouse cells, we identify a module of co …

The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory
receptors on CD4+ T cells promotes autoimmunity, whereas sustained overexpression on
CD8+ T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear
chronic viral infections and diseases such as cancer 1, 2. Here, using RNA and protein
expression profiling at single-cell resolution in mouse cells, we identify a module of co …