Infection with Leishmania major induces interleukin-12 production in vivo
LQ Vieira, BD Hondowicz, LCC Afonso, M Wysocka… - Immunology letters, 1994 - Elsevier
Experimental infections of mice with the protozoan parasite Leishmania major provide an
excellent model for defining the conditions required for generation of CD4+ Th1 and Th2
cells in vivo. Since interleukin-12 (IL-12) has been implicated in the development of Th1
cells, we investigated whether L. major stimulates IL-12 production in vitro or in vivo.
Surprisingly, macrophages cultured in vitro failed to produce IL-12 following L. major
infection. In contrast, lymph node cells from C3H mice infected for 2 days with L. major …
excellent model for defining the conditions required for generation of CD4+ Th1 and Th2
cells in vivo. Since interleukin-12 (IL-12) has been implicated in the development of Th1
cells, we investigated whether L. major stimulates IL-12 production in vitro or in vivo.
Surprisingly, macrophages cultured in vitro failed to produce IL-12 following L. major
infection. In contrast, lymph node cells from C3H mice infected for 2 days with L. major …
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