Meta-ethics is an important and fundamental part of ethical philosophy. Normative ethics discusses the ethical criterion and definition of happiness and obligation; but Meta-ethics deals with its background. In other words, it puts ethical propositions into philosophical questions in terms of meaning, cognition, and truth. In the intellectual system of transcendent wisdom, metaphysical issues and sheer philosophy are studied in order to help human beings to develop and transcend. In fact, human ethics and transcendence along with theology are two main goals of transcendent wisdom. In this regard, it is important to understand Mulla Sadra's views on meta-ethics as well as to discover and deduce it among Mulla Sadra's philosophical views. While defining meta-ethics, explaining its domains and asking main questions about each of these domains, the method of comparative study is used in this paper in order to provide the most appropriate and consistent possible answers to questions in the realm of meta-ethicsbased on Mulla Sadra's views on the originality of existence Substantial motion and Union of Intelligent and Intelligible and so on.