Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly

W Drew, DV Wilson, E Sapey - Experimental gerontology, 2018 - Elsevier
… an abnormal and sustained inflammatory response, with neutrophils being key effector cells
in … alteration of neutrophil functions in a number of chronic inflammatory diseases and during …

Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - … and Targeted Therapy, 2023 - nature.com
Immunosenescence of neutrophils occurs in a low-grade inflammatory environment, with
specific abnormalities in their metabolism and function, including decreased phagocytic …

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

E Sapey, H Greenwood, G Walton… - Blood, The Journal …, 2014 - ashpublications.org
… a range of inflammatory stimuli in migrating neutrophils isolated from healthy older subjects.
Cross… “bystander” tissue damage and heighten inflammation as a result of excess proteinase …

Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
neutrophils; this critically perpetuates the pro-inflammatory responses [64, 65]. Classically
activated macrophages are professional antigen-presenting cells (APCs) that can stimulate T-…

Immunosenescence: molecular mechanisms and diseases

Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - … and targeted therapy, 2023 - nature.com
… This chronic inflammation is a typical phenomenon linked to immunosenescence and it is
considered the major … Age-regulated tissue-specific macrophages and neutrophils may cause …

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

A Santoro, E Bientinesi, D Monti - Ageing research reviews, 2021 - Elsevier
… , immunosenescence has been considered detrimental because it may lead to a low-grade,
sterile chronic inflammation … The aged neutrophils (CD10 neg ) are accumulated in the skin …

Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients

I Maté, IM de Toda, L Arranz, JL Álvarez-Sala… - Experimental …, 2021 - Elsevier
… Thus, the purpose of the present work was to investigate several functions of circulating
neutrophils (adherence, chemotaxis, phagocytosis and superoxide anion stimulation capacity) …

[PDF][PDF] Inflammation and neutrophil immunosenescence in health and disease

W Drew, D Wilson, E Sapey - core.ac.uk
… an abnormal and sustained inflammatory response, with neutrophils being key effector cells
in … alteration of neutrophil functions in a number of chronic inflammatory diseases and during …

The role of immunosenescence in the development of age-related diseases

T Fülöp, G Dupuis, JM Witkowski… - Revista de investigacion …, 2016 - medigraphic.com
… Indeed, the number of neutrophils was reported to be relatively high in the elderly, …
inflammation related to immunosenescence contributes to the development of Alzheimer’s disease (…

Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
… to significant pro-inflammatory signalling and highlight the … immunosenescence, and
inflammation in driving poor health … and neutrophils, reduced levels of the most pro-inflammatory