BACKGROUND: A growing number of recent investigations have established a critical role
for leukocytes in propagating tissue damage after ischemia and reperfusion in stroke.
Experimental data obtained from animal models of middle cerebral artery occlusion
implicate inflammatory cell adhesion molecules, chemokines, and cytokines in the
pathogenesis of this ischemic damage. METHODS: Data from recent animal and human
studies were reviewed to demonstrate that inflammatory events occurring at the blood …