Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations

AM Teixeira, F Trevizol, G Colpo, SC Garcia… - Pharmacology …, 2008 - Elsevier
Several neurological diseases are related to oxidative stress (OS) and neurotoxicity.
Considering that physical exercise may exert beneficial effects on antioxidant defenses, our
objective was to evaluate the influence of a swimming exercise on an OS animal model
(reserpine-induced orofacial dyskinesia). In this model, the increased dopamine metabolism
can generate OS and neuronal degeneration, causing involuntary movements. The increase
in vacuous chewing movements and facial twitching caused by reserpine (1 mg/kg sc) was …
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