Glycogen–nucleic acid constructs ie, glycoplexes are emerging promising platforms for the
alteration of gene expression and transcription. Understanding the interaction of glycoplexes
with human blood components, such as serum proteins and peripheral blood mononuclear
cells (PBMCs), is important to overcome immune cell activation and control biodistribution
upon administration of the glycoplexes in vivo. Herein, we investigated the interactions of
polyethylene glycol (PEG) ylated and non-PEGylated glycoplexes carrying siRNA molecules …