Mineral admixture concrete is proved to be beneficial to enhance strength and resistance of concrete against aggressive chemical environment. However, water binder (w/b) ratio is the major responsible factor to govern all the concrete material properties. So, for a strong and durable concrete, it is imperative to design a proper mix with suitable w/b ratio. The present study investigates the effects of w/b ratio on the compressive strength and acid resistance property of mineral admixture incorporated concrete. Fly ash (FA) and crusher dust (CD) were used in concrete as partial cement replacement at the level of 20%, 40%, and 60% to cast concrete cube of size (150 × 150 × 150) mm³ using three w/b ratios of 0.35, 0.38 and 0.4. The fresh concrete properties, the compressive strength of the different types of concrete samples at 365 days of water curing and the acid (5% H₂SO₄) resistance of those water cured concrete samples after 365 days of acid exposure have been investigated to study the impact of w/b on the strength and acid resistance properties of concrete. Full factorial DOE with ANOVA was conducted to determine the significance of the concrete type and w/b ratio on strength and strength loss of concrete under acid exposure. In addition, the Grey relational Analysis and the Response Surface Methodology (RSM) have been also used to find the impact of w/b ratio towards simultaneous optimization of strength and % strength loss on acid exposure to concrete.