Unimanual left-right responses to up-down stimuli show a stimulus-response compatibility (SRC) effect for which the preferred mapping varies as a function of response eccentricity.Responses made in the right hemispace and, to a lesser extent, at a midline position, are faster with the up-right/ down-left mapping than with the up-left/down-right mapping, but responses made in the left hemispace are faster with the up-left/down-right mapping.Also, for responses at the midline position, the preferred mapping switches when the hand is placed in a supine posture instead of the more usual prone posture.The response eccentricity effect can be explained in terms of correspondence of asymmetrically coded stimulus and response features, but it is not obvious whether the hand posture effect can be explained in a similar manner.The present study tested the implications of a hypothesis that the body of the hand provides a frame of reference with respect to which the response switch is coded as left or right.As was predicted by this hand referent hypothesis, Experiment 1 showed that the influence of hand posture (prone and supine) on orthogonal SRC was additive with that of response location. In Experiment 2, the location of the switch relative to the hand was varied by having subjects use either a normal grip in which the switch was held between the thumb and the index finger or a grip in which it was held between the little and the ring fingers.The magnitudes of the mapping preferences varied as a function of the grip and hand posture in a manner consistent with the hand referent hypothesis.