Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5
ABSTRACT Chicken MDA5 (chMDA5), the sole known pattern recognition receptor for
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious
bursal disease virus (IBDV) evades host innate immunity, but the mechanism is unclear. We
report here that IBDV inhibited antiviral innate immunity via the chMDA5-dependent
signaling pathway. IBDV infection did not induce efficient type I interferon (IFN) production
but antagonized the antiviral activity of beta interferon (IFN-β) in DF-1 cells pretreated with …
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious
bursal disease virus (IBDV) evades host innate immunity, but the mechanism is unclear. We
report here that IBDV inhibited antiviral innate immunity via the chMDA5-dependent
signaling pathway. IBDV infection did not induce efficient type I interferon (IFN) production
but antagonized the antiviral activity of beta interferon (IFN-β) in DF-1 cells pretreated with …
Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5.
YCJ Ye ChengJin, JL Jia Lu, SYT Sun YanTing… - 2014 - cabidigitallibrary.org
Abstract Chicken MDA5 (chMDA5), the sole known pattern recognition receptor for
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious
bursal disease virus (IBDV) evades host innate immunity, but the mechanism is unclear. We
report here that IBDV inhibited antiviral innate immunity via the chMDA5-dependent
signaling pathway. IBDV infection did not induce efficient type I interferon (IFN) production
but antagonized the antiviral activity of beta interferon (IFN-β) in DF-1 cells pretreated with …
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious
bursal disease virus (IBDV) evades host innate immunity, but the mechanism is unclear. We
report here that IBDV inhibited antiviral innate immunity via the chMDA5-dependent
signaling pathway. IBDV infection did not induce efficient type I interferon (IFN) production
but antagonized the antiviral activity of beta interferon (IFN-β) in DF-1 cells pretreated with …