… Here we show that long-term inhibition of mTOR by rapamycin prevented AD-like … -term
mTOR inhibition by rapamycin inhibited mTOR in brain, prevented AD-like cognitive deficits (Fig. …

… mTOR is an inhibitor of macroautophagy, which is a conserved intracellular system … In
this study we report the effects of reducing mTOR signaling on the neuropathological and …

… all the current findings on the use of mTOR inhibitors (rapamycin, rapalogues) in the … mTOR
inhibitors as potential therapeutic agents able to reduce AD hallmarks and recover cognitive …

… increases the rapamycin-reduced phosphorylation of mTOR, indicating its inhibitory effect
… We also report here that administration of RAP resulted in significant inhibition of mTOR and …

… For inhibition of the mTOR signal, rapamycin was used to reduce the activity of … stimulation
and rapamycin is a well known mTOR inhibitor, the present study investigated the effect of …

… increased amyloid-β clearance by promoting autophagy, as well as … -term inhibition of mTOR
by rapamycin was shown to prevent cognitive deficits associated with AD and reduce levels …

… the molecular level, AD is characterized by overt amyloid β (… , in mice, the chronic inhibition
of mTOR by rapamycin not only … reported that rapamycin could decrease tau phosphorylation …

… cognitive scores in behavioral tests, reduced amyloid-β 1-40 plaque deposition, and reduced
soluble Aβ1-40 and Aβ1-42 levels in … through inhibition with rapamycin reversed cognitive …

… We concluded that use of rapamycin, an MTOR inhibitor that … complex subunit 1) reduces
amyloid-β 42 accumulation and … sensitive to rapamycin-induced increases in amyloid-β 42 …

… tangles, comprised primarily of amyloid-β (Aβ) and tau, … mTOR as it demonstrated that
reducing high levels of mTOR … showed that inhibition of mTOR by rapamycin suppresses tau …