Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
F Matthes, MM Hettich, J Schilling… - Cell death …, 2018 - nature.com
Alzheimer's disease (AD) is characterized by two neuropathological hallmarks: senile
plaques, which are composed of amyloid-β (Aβ) peptides, and neurofibrillary tangles, which
are composed of hyperphosphorylated tau protein. Aβ peptides are derived from sequential
proteolytic cleavage of the amyloid precursor protein (APP). In this study, we identified a so
far unknown mode of regulation of APP protein synthesis involving the MID1 protein
complex: MID1 binds to and regulates the translation of APP mRNA. The underlying mode of …
plaques, which are composed of amyloid-β (Aβ) peptides, and neurofibrillary tangles, which
are composed of hyperphosphorylated tau protein. Aβ peptides are derived from sequential
proteolytic cleavage of the amyloid precursor protein (APP). In this study, we identified a so
far unknown mode of regulation of APP protein synthesis involving the MID1 protein
complex: MID1 binds to and regulates the translation of APP mRNA. The underlying mode of …
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