… Besides these two drugs, many other small molecule inhibitors are currently in various
stages of clinical trials. … treatment methods to increase the survival rate of patients. The VEGF …

… HK specifically, an interesting target for glycolysis inhibition in cancer treatment. Hence,
multiple HK inhibitors are in preclinical and clinical Phase trials, in particular the following. …

… -negative, depending on the method used to measure the expression of the receptor, when
indeed, cells with vIII mutations are inhibited by some of these compounds (105). The lack of …

… Methods: Primary literature and patents were … Compound 34 was reported to inhibit a
variety of tumors in vivo and had been in early clinical trials at Pfizer for the treatment of cancer…

… An isosteric scaffold of adenosine, the 4-aminopyrido[2,3-d]pyrimidine derivative API-1 was
discovered to inhibit Akt by screening the DTP/NCI compound library in a cell-based assay. …

… therapy method for cancers. Consequently, a number of small molecules with CDK inhibitory
… [1,5-a]pyridine compounds as inhibitors of CDKs are used in the treatment, prevention, …

… EGFR inhibitors and FDA-approved drugs for cancer treatment. EGFR inhibitors function
either … The theoretical methods employed to compare the chemical and biological activities of …

… the therapeutic options targeting survivin for cancer treatment is analyzed. Direct survivin
inhibitors … -based approaches, together with chemotherapeutic drugs to efficiently treat cancer. …

… Although many of these compounds are potent proteasome inhibitors, all but CEP1612
and … who were refractory to their current therapy or had no other standard therapy options …

… To date, few treatment options exist besides surgical resection and this is frequently not …
and to find small-molecule compounds that inhibit FAK function and decrease cell viability and …