Inhibitors of HIF-1α and CXCR4 mitigate the development of radiation necrosis in mouse brain
Purpose There is mounting evidence that, in addition to angiogenesis, hypoxia-induced
inflammation via the hypoxia-inducible factor 1α (HIF-1α)–CXC chemokine receptor 4
(CXCR4) pathway may contribute to the pathogenesis of late-onset, irradiation-induced
necrosis. This study investigates the mitigative efficacy of an HIF-1α inhibitor, topotecan, and
a CXCR4 antagonist, AMD3100, on the development of radiation necrosis (RN) in an
intracranial mouse model. Methods and Materials Mice received a single-fraction, 50-Gy …
inflammation via the hypoxia-inducible factor 1α (HIF-1α)–CXC chemokine receptor 4
(CXCR4) pathway may contribute to the pathogenesis of late-onset, irradiation-induced
necrosis. This study investigates the mitigative efficacy of an HIF-1α inhibitor, topotecan, and
a CXCR4 antagonist, AMD3100, on the development of radiation necrosis (RN) in an
intracranial mouse model. Methods and Materials Mice received a single-fraction, 50-Gy …
以上显示的是最相近的搜索结果。 查看全部搜索结果