Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may
result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves
rapid reperfusion. However, a highly dynamic and co-ordinated inflammatory response is
rapidly mounted to repair and remove the injured cells which, paradoxically, can further
exacerbate myocardial injury. Furthermore, although cardiac remodelling may initially
preserve some function to the heart, it can lead over time to adverse remodelling and …

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(s) 2018. For permissions, please email: journals. permissions@ oup. com. Acute
obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may result in
an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves rapid
reperfusion. However, a highly dynamic and co-ordinated inflammatory response is rapidly
mounted to repair and remove the injured cells which, paradoxically, can further exacerbate …