Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers–a Swiss contribution
Chimia, 2010•chimia.ch
Innovative mixing principles in bioreactors, for example using the rocking of a platform to
induce a backwards and forwards' wave', or using orbital shaking to generate a'wave'that
runs round in a cylindrical container, have proved to be successful for the suspension
cultures of cells, especially when combined with disposable materials. This article presents
an overview of the engineering characteristics when these new principles are applied in
bioreactors, and case studies covering scales of operation from milliliters to 1000 liters.
induce a backwards and forwards' wave', or using orbital shaking to generate a'wave'that
runs round in a cylindrical container, have proved to be successful for the suspension
cultures of cells, especially when combined with disposable materials. This article presents
an overview of the engineering characteristics when these new principles are applied in
bioreactors, and case studies covering scales of operation from milliliters to 1000 liters.
Abstract
Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards' wave', or using orbital shaking to generate a'wave'that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 liters.
chimia.ch
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