Innovative human three-dimensional tissue-engineered models as an alternative to animal testing

P Bédard, S Gauvin, K Ferland, C Caneparo, È Pellerin… - Bioengineering, 2020 - mdpi.com
Innovative models became essential to develop more accurate knowledge. Tissue engineering
provides some of those models… organ-specific human-derived three-dimensional models

A three-dimensional human tissue-engineered lung model to study influenza A infection

R Bhowmick, T Derakhshan, Y Liang… - … Engineering Part A, 2018 - liebertpub.com
… immune responses to IAV as it lacks the three-dimensional (3D) tissue structure. To … Human
Tissue-Engineered Lung Model (3D-HTLM), we describe the 3D culture of primary human

Tissue-engineered 3D tumor angiogenesis models: potential technologies for anti-cancer drug discovery

K Chwalek, LJ Bray, C Werner - Advanced drug delivery reviews, 2014 - Elsevier
… for improvement of existing research models, which engages … new model to study tumor
angiogenesis result in innovative … challenges in three-dimensional tissue-engineered models for …

Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
… , where cells grow within a complex three-dimensional (3D) … to develop tissue-engineered
human models by summarizing … Union's Horizon 2020 research and innovation programme (…

Introducing the concept of the 3Rs into tissue engineering research

C Eder, E Falkner, S Nehrer, UM Losert… - … to animal experimentation, 2006 - altex.org
… prior to implantation of a tissue engineered product. Animal experirnentation for the evaluation
of safety … Three dimensional cell culture increased collagen type land 11synthesis in FCS …

Human engineered cartilage and decellularized matrix as an alternative to animal osteoarthritis model

M Galuzzi, S Perteghella, B Antonioli, MC Tosca, E Bari… - Polymers, 2018 - mdpi.com
… of new drugs, 3D models can be used to test a large number of … 3D models can not totally
substitute animal testing, but could … Therefore, three-dimensional models, able to mimic the …

Anti-cancer drug validation: the contribution of tissue engineered models

MR Carvalho, D Lima, RL Reis, JM Oliveira… - Stem Cell Reviews and …, 2017 - Springer
… 2D assays and animal studies have limitations that cannot … the development of three-dimensional
(3D) models. The … an innovative three-dimensional (3D) lung carcinoma models

Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing

A Holmes, R Brown, K Shakesheff - Regenerative medicine, 2009 - Taylor & Francis
animal testing, therefore reducing subsequent animal use. … Tissue engineered models of
the airway have already … The examples in this review demonstrate the need for innovative

Intelligent Biomatrices and Engineered Tissue Constructs: In‐Vitro Models for Drug Discovery and Toxicity Testing

P Lazarovici, M Li, A Perets… - Drug Testing In Vitro …, 2006 - Wiley Online Library
… as pharmacological test-beds, more realistic three-dimensional (3D… We believe that
tissue-engineered model systems of 3D … -fidelity BBB model highlights the urgent need for …

Biomimetic 3D tissue models for advanced high-throughput drug screening

KH Nam, AST Smith, S Lone… - Journal of laboratory …, 2015 - journals.sagepub.com
… In recent years, innovations in drug delivery systems have seen enormous growth, …
tissue-engineered models of hepatic tissue also have an important potential role in preclinical …